The New York Consortium in Evolutionary Primatology
Associate Professor Neurobiology and Anatomy Drexel University College of Medicine
Ph.D. 2001, City University of New York
Tel: (215) 991-8467
Fax: (215) 843-9082
My research in bone biology aims to improve our understanding of variability in microstructural and geometric properties of bone. I am interested in understanding how the size and shape of whole bones, as well as the distribution, quantity and quality of the mineralized tissue that forms the bone, reflect both constraints of skeletal growth and development, and responsiveness to mechanical loading during life. My research has focused on examining changes in bone quality with age in humans, including selected material (i.e. histological composition) and structural (i.e. geometric shape) properties of bone. This research has applications to both the study of age related bone diseases such as osteoporosis, as well as to the reconstruction of health and activities of past populations (through the study of archaeological skeletal remains).
My current research activities include studies of bone growth and development in order to better understand how these processes influence the attainment of adult bone morphology and quality at macrostructural, microstructural and nanostructural length scales. I am also interested in further integrating analyses of bone microstructure with theoretical modeling of the biomechanics of human locomotion, in an effort to better understand how changes in bone structure affect fracture risk.
I have recently established the Bone Biology Laboratory, which is dedicated to the study of bone quality, structure and adaptation during growth, aging and disease. The laboratory is located at Drexel's Queen Lane campus, established with support from the Department of Orthopedic Surgery. The facility will provide Drexel students and residents new opportunities to participate in bone biology research, as well as to foster interdisciplinary research in musculoskeletal biology between Basic Science, Clinical Orthopedics and Engineering disciplines.
Price, C., Herman, B.C., Lufkin, T., Goldman, H.M. and Kepsen, K.J. (2005) Genetic Variation in Bone Growth Patterns Defines Adult Mouse Bone Fragility. Journal of Bone and Mineral Research 20(11):1983-91.
Goldman, H.M., Clement, J.G., Thomas, C.D.L. and Bromage, T.G. (2005) Relationships among microstructural properties of bone at the human mid-shaft femur. Journal of Anatomy. 206:127-139.
Goldman, H.M., Bromage, T.G., Boyde, A., Thomas, C.D.L. and Clement, J.G. (2003). Intrapopulation Variability in Mineralization Density at the Human Femoral Mid-Shaft. Journal of Anatomy 203: 243-255.
Bromage, T.G., Goldman, H.M., McFarlin, S., Warshaw, J., Boyde, A. and Riggs, C.M. (2003). Circularly polarized light standards for investigations of collagen fiber orientation in bone. The New Anatomist 274B:157-168.
Goldman, H.M., Bromage, T.G., Thomas, C.D.L. and Clement, J.G. (2003). Preferred Collagen Fiber Orientation at the Human Mid-Shaft Femur. The Anatomical Record 272A: 434-445. (Figure selected for cover micrograph).
Goldman, H. M., Bromage, T. G., Blayvas, A., Boyde, A., Howell, P. & Clement, J.G. (2000). Correlative Light and Backscattered Electron Microscopy of Human Bone. Part II: Automated Image Analysis. Scanning 22(6): 337-344. (Figure selected for cover micrograph)
Goldman, H. M., Kindsvater, J. & Bromage, T. G. (1999). Correlative Light and Backscattered Electron Microscopy of Bone. Part I: Specimen Preparation Methods. Scanning 21(1): 40-43.